Ontology highlight
ABSTRACT:
SUBMITTER: Gerland U
PROVIDER: S-EPMC2690017 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Gerland Ulrich U Hwa Terence T
Proceedings of the National Academy of Sciences of the United States of America 20090522 22
Microorganisms employ a wealth of gene regulatory mechanisms to adjust their growth programs to variations in the environment. It was pointed out long ago [Savageau M (1977) Proc Natl Acad Sci USA 74: 5647-5651] that the particular mode of gene regulation employed may be correlated with the "demand" on the regulated gene, i.e., how frequently the gene product is needed in its natural habitat. An evolutionary "use-it-or-lose-it" principle was proposed to govern the choice of gene regulatory strat ...[more]