Ontology highlight
ABSTRACT:
SUBMITTER: Innocenti F
PROVIDER: S-EPMC2690389 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Innocenti Federico F Kroetz Deanna L DL Schuetz Erin E Dolan M Eileen ME Ramírez Jacqueline J Relling Mary M Chen Peixian P Das Soma S Rosner Gary L GL Ratain Mark J MJ
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090406 16
<h4>Purpose</h4>We aim to identify genetic variation, in addition to the UGT1A1*28 polymorphism, that can explain the variability in irinotecan (CPT-11) pharmacokinetics and neutropenia in cancer patients.<h4>Patients and methods</h4>Pharmacokinetic, genetic, and clinical data were obtained from 85 advanced cancer patients treated with single-agent CPT-11 every 3 weeks at doses of 300 mg/m(2) (n = 20) and 350 mg/m(2) (n = 65). Forty-two common variants were genotyped in 12 candidate genes of the ...[more]