Ontology highlight
ABSTRACT:
SUBMITTER: Moradkhani K
PROVIDER: S-EPMC2690850 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Moradkhani Kamran K Préhu Claude C Old John J Henderson Shirley S Balamitsa Vera V Luo Hong-Yuan HY Poon Man-Chiu MC Chui David H K DH Wajcman Henri H Patrinos George P GP
Annals of hematology 20081016 6
The human alpha-globin genes are paralogues, sharing a high degree of DNA sequence similarity and producing an identical alpha-globin chain. Over half of the alpha-globin structural variants reported to date are only characterized at the amino acid level. It is likely that a fraction of these variants, with phenotypes differing from one observation to another, may be due to the same mutation but on a different alpha-globin gene. There have been very few previous examples of hemoglobin variants t ...[more]