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Endoplasmic reticulum stress is implicated in retinal inflammation and diabetic retinopathy.


ABSTRACT: Diabetic retinopathy is a chronic low-grade inflammatory disease; however, the mechanisms remain elusive. In the present study, we demonstrated that endoplasmic reticulum (ER) stress was activated in the retina in animal models of diabetes and oxygen-induced retinopathy (OIR). Induction of ER stress by tunicamycin resulted in significantly increased expression of inflammatory molecules in the retina. Inhibition of ER stress by chemical chaperone 4-phenyl butyric acid ameliorated inflammation in cultured human retinal endothelial cells exposed to hypoxia, and in the retinas of diabetic and OIR mice. These findings indicate that ER stress is a potential mediator of retinal inflammation in diabetic retinopathy.

SUBMITTER: Li J 

PROVIDER: S-EPMC2691649 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature

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Endoplasmic reticulum stress is implicated in retinal inflammation and diabetic retinopathy.

Li Jingming J   Wang Joshua J JJ   Yu Qiang Q   Wang Min M   Zhang Sarah X SX  

FEBS letters 20090411 9


Diabetic retinopathy is a chronic low-grade inflammatory disease; however, the mechanisms remain elusive. In the present study, we demonstrated that endoplasmic reticulum (ER) stress was activated in the retina in animal models of diabetes and oxygen-induced retinopathy (OIR). Induction of ER stress by tunicamycin resulted in significantly increased expression of inflammatory molecules in the retina. Inhibition of ER stress by chemical chaperone 4-phenyl butyric acid ameliorated inflammation in  ...[more]

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