Ontology highlight
ABSTRACT:
SUBMITTER: Li J
PROVIDER: S-EPMC2691649 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Li Jingming J Wang Joshua J JJ Yu Qiang Q Wang Min M Zhang Sarah X SX
FEBS letters 20090411 9
Diabetic retinopathy is a chronic low-grade inflammatory disease; however, the mechanisms remain elusive. In the present study, we demonstrated that endoplasmic reticulum (ER) stress was activated in the retina in animal models of diabetes and oxygen-induced retinopathy (OIR). Induction of ER stress by tunicamycin resulted in significantly increased expression of inflammatory molecules in the retina. Inhibition of ER stress by chemical chaperone 4-phenyl butyric acid ameliorated inflammation in ...[more]