Ontology highlight
ABSTRACT:
SUBMITTER: Wood J
PROVIDER: S-EPMC2691801 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Wood James J McCaw James J Becker Niels N Nolan Terry T MacIntyre C Raina CR
American journal of epidemiology 20090424 12
Limited production capacity and delays inherent in vaccine development are major hurdles to the widespread use of vaccines to mitigate the effects of a new influenza pandemic. Antigen-sparing vaccines have the most potential to increase population coverage but may be less efficacious. The authors explored this trade-off by applying simple models of influenza transmission and dose response to recent clinical trial data. In this paper, these data are used to illustrate an approach to comparing vac ...[more]