Ontology highlight
ABSTRACT:
SUBMITTER: de Jong A
PROVIDER: S-EPMC2692252 | biostudies-literature | 2007 Nov
REPOSITORIES: biostudies-literature
Chemistry & biology 20071101 11
Human CD1c is a protein that activates alphabeta T cells by presenting self antigens, synthetic mannosyl phosphodolichols, and mycobacterial mannosyl phosphopolyketides. To determine which molecular features of antigen structure confer a T cell response, we measured activation by structurally divergent Mycobacterium tuberculosis mannosyl-beta1-phosphomycoketides and synthetic analogs with either stereorandom or stereospecific methyl branching patterns. T cell responses required both a phosphate ...[more]