Ontology highlight
ABSTRACT:
SUBMITTER: Linding R
PROVIDER: S-EPMC2692296 | biostudies-literature | 2007 Jun
REPOSITORIES: biostudies-literature
Cell 20070614 7
Protein kinases control cellular decision processes by phosphorylating specific substrates. Thousands of in vivo phosphorylation sites have been identified, mostly by proteome-wide mapping. However, systematically matching these sites to specific kinases is presently infeasible, due to limited specificity of consensus motifs, and the influence of contextual factors, such as protein scaffolds, localization, and expression, on cellular substrate specificity. We have developed an approach (NetworKI ...[more]