Ontology highlight
ABSTRACT:
SUBMITTER: Li J
PROVIDER: S-EPMC2692305 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
Bioorganic & medicinal chemistry 20070901 24
Continuing from our ongoing effort in modifying aminoglycoside antibiotics with the goal of counteracting drug resistant bacteria, we have further derivatized pyranmycin, a neomycin class aminoglycoside antibiotic, with modifications at O-6 and N-1 positions. The revealed SAR results demonstrated that the antibacterial activity of pyranmycin can be modulated by different acylic substituents at O-6. Among these results, the 6-O-aminoethyl derivative, JT050, showed effective activity against resis ...[more]