Ontology highlight
ABSTRACT:
SUBMITTER: Wallin S
PROVIDER: S-EPMC2692925 | biostudies-literature | 2007 May
REPOSITORIES: biostudies-literature
Wallin Stefan S Zeldovich Konstantin B KB Shakhnovich Eugene I EI
Journal of molecular biology 20070222 3
An increasing number of proteins are being discovered with a remarkable and somewhat surprising feature, a knot in their native structures. How the polypeptide chain is able to "knot" itself during the folding process to form these highly intricate protein topologies is not known. Here we perform a computational study on the 160-amino-acid homodimeric protein YibK, which, like other proteins in the SpoU family of MTases, contains a deep trefoil knot in its C-terminal region. In this study, we us ...[more]