Ontology highlight
ABSTRACT:
SUBMITTER: Akoum R
PROVIDER: S-EPMC2692982 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Akoum Riad R Ghaoui Albert A Brihi Emile E Ghabash Maroun M Hajjar Nicolas N
Hereditary cancer in clinical practice 20090528 1
<h4>Background</h4>There are still controversies about the integration of breast cancer as a part of the disease spectrum in Lynch syndrome.<h4>Methods</h4>A regular follow-up of a Lebanese pedigree with Lynch syndrome due to a point mutation of MSH2 gene at the splice donor site of intron 3 started in 1996.<h4>Results</h4>A 26-year-old pregnant woman, mutation carrier, developed an aggressive breast cancer, refractory to standard chemotherapy regimens. The microsatellite analysis of the tumor s ...[more]