Ontology highlight
ABSTRACT:
SUBMITTER: Nathans R
PROVIDER: S-EPMC2693000 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Nathans Robin R Cao Hong H Sharova Natalia N Ali Akbar A Sharkey Mark M Stranska Ruzena R Stevenson Mario M Rana Tariq M TM
Nature biotechnology 20080921 10
The HIV-1 protein Vif, essential for in vivo viral replication, targets the human DNA-editing enzyme, APOBEC3G (A3G), which inhibits replication of retroviruses and hepatitis B virus. As Vif has no known cellular homologs, it is an attractive, yet unrealized, target for antiviral intervention. Although zinc chelation inhibits Vif and enhances viral sensitivity to A3G, this effect is unrelated to the interaction of Vif with A3G. We identify a small molecule, RN-18, that antagonizes Vif function a ...[more]