Ontology highlight
ABSTRACT:
SUBMITTER: Klaikherd A
PROVIDER: S-EPMC2693022 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Klaikherd Akamol A Nagamani Chikkannagari C Thayumanavan S S
Journal of the American Chemical Society 20090401 13
Stimuli-responsive polymers are arguably the most widely considered systems for a variety of applications in biomedical arena. We report here a novel triple stimuli sensitive block copolymer assembly that responds to changes in temperature, pH and redox potential. Our block copolymer design constitutes an acid-sensitive THP-protected HEMA as the hydrophobic part and a temperature-sensitive PNIPAM as the hydrophilic part with an intervening disulfide bond. The micellar properties and the release ...[more]