Ontology highlight
ABSTRACT:
SUBMITTER: Lewis JC
PROVIDER: S-EPMC2693036 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20080202 8
A practical, functional group tolerant method for the Rh-catalyzed direct arylation of a variety of pharmaceutically important azoles with aryl bromides is described. Many of the successful azole and aryl bromide coupling partners are not compatible with methods for the direct arylation of heterocycles using Pd(0) or Cu(I) catalysts. The readily prepared, low molecular weight ligand, Z-1-tert-butyl-2,3,6,7-tetrahydrophosphepine, which coordinates to Rh in a bidentate P-olefin fashion to provide ...[more]