Ontology highlight
ABSTRACT:
SUBMITTER: Abe K
PROVIDER: S-EPMC2693145 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Abe Kazuhiro K Tani Kazutoshi K Nishizawa Tomohiro T Fujiyoshi Yoshinori Y
The EMBO journal 20090423 11
The gastric H(+),K(+)-ATPase is an ATP-driven proton pump responsible for generating a million-fold proton gradient across the gastric membrane. We present the structure of gastric H(+),K(+)-ATPase at 6.5 A resolution as determined by electron crystallography of two-dimensional crystals. The structure shows the catalytic alpha-subunit and the non-catalytic beta-subunit in a pseudo-E(2)P conformation. Different from Na(+),K(+)-ATPase, the N-terminal tail of the beta-subunit is in direct contact w ...[more]