Ontology highlight
ABSTRACT:
SUBMITTER: Grimm C
PROVIDER: S-EPMC2693881 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Grimm Clemens C Matos Raquel R Ly-Hartig Nga N Steuerwald Ulrich U Lindner Doris D Rybin Vladimir V Müller Jürg J Müller Christoph W CW
The EMBO journal 20090604 13
Polycomb group (PcG) proteins repress transcription by modifying chromatin structure in target genes. dSfmbt is a subunit of the Drosophila melanogaster PcG protein complex PhoRC and contains four malignant brain tumour (MBT) repeats involved in the recognition of various mono- and dimethylated histone peptides. Here, we present the crystal structure of the four-MBT-repeat domain of dSfmbt in complex with a mono-methylated histone H4 peptide. Only a single histone peptide binds to the four-MBT-r ...[more]