Ontology highlight
ABSTRACT:
SUBMITTER: Su X
PROVIDER: S-EPMC2694509 | biostudies-literature | 2007 May
REPOSITORIES: biostudies-literature
Su Xiaodan X Jacob Naduparambil K NK Amunugama Ravindra R Lucas David M DM Knapp Amy R AR Ren Chen C Davis Melanie E ME Marcucci Guido G Parthun Mark R MR Byrd John C JC Fishel Richard R Freitas Michael A MA
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070107 1-2
Here we describe the use of reverse-phase liquid chromatography mass spectrometry (RPLC-MS) to simultaneously characterize variants and post-translationally modified isoforms for each histone. The analysis of intact proteins significantly reduces the time of sample preparation and simplifies data interpretation. LC-MS analysis and peptide mass mapping have previously been applied to identify histone proteins and to characterize their post-translational modifications. However, these studies provi ...[more]