Ontology highlight
ABSTRACT:
SUBMITTER: Coloma R
PROVIDER: S-EPMC2695768 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Coloma Rocío R Valpuesta José M JM Arranz Rocío R Carrascosa José L JL Ortín Juan J Martín-Benito Jaime J
PLoS pathogens 20090626 6
The influenza viruses contain a segmented, single-stranded RNA genome of negative polarity. Each RNA segment is encapsidated by the nucleoprotein and the polymerase complex into ribonucleoprotein particles (RNPs), which are responsible for virus transcription and replication. Despite their importance, information about the structure of these RNPs is scarce. We have determined the three-dimensional structure of a biologically active recombinant RNP by cryo-electron microscopy. The structure shows ...[more]