A dual leucine kinase-dependent axon self-destruction program promotes Wallerian degeneration.
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ABSTRACT:
SUBMITTER: Miller BR
PROVIDER: S-EPMC2696160 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Publications
A dual leucine kinase-dependent axon self-destruction program promotes Wallerian degeneration.
Miller Bradley R BR Press Craig C Daniels Richard W RW Sasaki Yo Y Milbrandt Jeffrey J DiAntonio Aaron A
Nature neuroscience 20090315 4
Axon degeneration underlies many common neurological disorders, but the signaling pathways that orchestrate axon degeneration are unknown. We found that dual leucine kinase (DLK) [corrected to add (DLK) abbreviation] promoted degeneration of severed axons in Drosophila and mice, and that its target, c-Jun N-terminal kinase, promoted degeneration locally in axons as they committed to degenerate. This pathway also promoted degeneration after chemotherapy exposure and may be a component of a genera ...[more]
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