Ontology highlight
ABSTRACT:
SUBMITTER: Clemson CM
PROVIDER: S-EPMC2696186 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Clemson Christine M CM Hutchinson John N JN Sara Sergio A SA Ensminger Alexander W AW Fox Archa H AH Chess Andrew A Lawrence Jeanne B JB
Molecular cell 20090212 6
NEAT1 RNA, a highly abundant 4 kb ncRNA, is retained in nuclei in approximately 10 to 20 large foci that we show are completely coincident with paraspeckles, nuclear domains implicated in mRNA nuclear retention. Depletion of NEAT1 RNA via RNAi eradicates paraspeckles, suggesting that it controls sequestration of the paraspeckle proteins PSP1 and p54, factors linked to A-I editing. Unlike overexpression of PSP1, NEAT1 overexpression increases paraspeckle number, and paraspeckles emanate exclusive ...[more]