Ontology highlight
ABSTRACT:
SUBMITTER: Crooke CE
PROVIDER: S-EPMC2696586 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Crooke Cornelia E CE Pozzi Ambra A Carpenter Graham F GF
Experimental cell research 20090418 13
Phospholipase C-gamma1 (PLC-gamma1) mediates cell adhesion and migration through an undefined mechanism. Here, we examine the role of PLC-gamma1 in cell-matrix adhesion in a hanging drop assay of cell aggregation. Plcg1 Null (-/-) mouse embryonic fibroblasts formed aggregates that were larger and significantly more resistant to dissociation than cells in which PLC-gamma1 is re-expressed (Null+ cells). Aggregate formation could be disrupted by inhibition of fibronectin interaction with integrins, ...[more]