Time-dependent inactivation of human phenylethanolamine N-methyltransferase by 7-isothiocyanatotetrahydroisoquinoline.
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ABSTRACT:
SUBMITTER: Wu Q
PROVIDER: S-EPMC2696812 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Publications
Time-dependent inactivation of human phenylethanolamine N-methyltransferase by 7-isothiocyanatotetrahydroisoquinoline.
Wu Qian Q Caine Joanne M JM Thomson Stuart A SA Slavica Meri M Grunewald Gary L GL McLeish Michael J MJ
Bioorganic & medicinal chemistry letters 20090110 4
Inhibitors of phenylethanolamine N-methyltransferase [PNMT, the enzyme that catalyzes the final step in the biosynthesis of epinephrine (Epi)] may be of use in determining the role of Epi in the central nervous system. Here we describe the synthesis and characterization of 7-SCN tetrahydroisoquinoline as an affinity label for human PNMT. ...[more]
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