Amyloid beta protein: Abeta40 inhibits Abeta42 oligomerization.
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ABSTRACT:
SUBMITTER: Murray MM
PROVIDER: S-EPMC2697393 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Publications
Amyloid beta protein: Abeta40 inhibits Abeta42 oligomerization.
Murray Megan M MM Bernstein Summer L SL Nyugen Vy V Condron Margaret M MM Teplow David B DB Bowers Michael T MT
Journal of the American Chemical Society 20090501 18
Abeta40 and Abeta42 are peptides that adopt similar random-coil structures in solution. Abeta42, however, is significantly more neurotoxic than Abeta40 and forms amyloid fibrils much more rapidly than Abeta40. Here, mass spectrometry and ion mobility spectrometry are used to investigate a mixture of Abeta40 and Abeta42. The mass spectrum for the mixed solution shows the presence of a heterooligomer composed of equal parts of Abeta40 and Abeta42. Ion mobility results indicate that this mixed spec ...[more]
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