Ontology highlight
ABSTRACT:
SUBMITTER: Jensen KB
PROVIDER: S-EPMC2698066 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Jensen Kim B KB Collins Charlotte A CA Nascimento Elisabete E Tan David W DW Frye Michaela M Itami Satoshi S Watt Fiona M FM
Cell stem cell 20090501 5
Lrig1 is a marker of human interfollicular epidermal stem cells and helps maintain stem cell quiescence. We show that, in mouse epidermis, Lrig1 defines the hair follicle junctional zone adjacent to the sebaceous glands and infundibulum. Lrig1 is a Myc target gene; loss of Lrig1 increases the proliferative capacity of stem cells in culture and results in epidermal hyperproliferation in vivo. Lrig1-expressing cells can give rise to all of the adult epidermal lineages in skin reconstitution assays ...[more]