Effects of calcium supplementation on body weight and adiposity in overweight and obese adults: a randomized trial.
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ABSTRACT: BACKGROUND:Some data suggest that increasing calcium intake may help prevent weight gain. OBJECTIVE:To test the hypothesis that calcium supplementation can prevent weight gain in persons who are overweight or obese. DESIGN:Randomized, placebo-controlled trial. Randomization was computer-generated, and allocation was assigned by pharmacy personnel who prepared intervention and placebo capsules. Participants, providers, and those who assessed outcomes were blinded to study group assignment. SETTING:Single research center. PARTICIPANTS:340 overweight (body mass index [BMI], 25 to <30 kg/m(2)) and obese (BMI > or =30 kg/m(2)) adults (mean age, 38.8 years [SD, 10.5]). INTERVENTION:Calcium carbonate (elemental calcium, 1500 mg/d) (n = 170) or placebo (n = 170) with meals for 2 years. MEASUREMENTS:Changes in body weight and fat mass (primary outcomes). RESULTS:Seventy-five percent of participants completed the trial (78% received calcium; 73% received placebo). There were no statistically or clinically significant differences between the calcium and placebo groups in change in body weight (difference, 0.02 kg [95% CI, -1.64 to 1.69 kg]; P = 0.98), BMI (difference, 0.32 kg/m(2) [CI, -0.41 to 1.02 kg/m(2)]; P = 0.39), or body fat mass (difference, 0.39 kg [CI, -1.04 to 1.92 kg]; P = 0.55). Parathyroid hormone concentrations decreased in the calcium group compared with the placebo group (difference, -0.71 pmol/L [CI, -1.28 to -0.13 pmol/L]). LIMITATION:The study took place at a research center, and its sample was mostly women. CONCLUSION:Dietary supplementation with elemental calcium, 1500 mg/d, for 2 years had no statistically or clinically significant effects on weight in overweight and obese adults. Calcium supplementation is unlikely to have clinically significant efficacy as a preventive measure against weight gain in such patients.
SUBMITTER: Yanovski JA
PROVIDER: S-EPMC2698127 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
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