Genomic sequencing reveals regulatory mutations and recombinational events in the widely used MC4100 lineage of Escherichia coli K-12.
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ABSTRACT:
SUBMITTER: Ferenci T
PROVIDER: S-EPMC2698400 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
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Genomic sequencing reveals regulatory mutations and recombinational events in the widely used MC4100 lineage of Escherichia coli K-12.
Ferenci Thomas T Zhou Zhemin Z Betteridge Thu T Ren Yan Y Liu Yu Y Feng Lu L Reeves Peter R PR Wang Lei L
Journal of bacteriology 20090417 12
The genome of an Escherichia coli MC4100 strain with a lambda placMu50 fusion revealed numerous regulatory differences from MG1655, including one that arose during laboratory storage. The 194 mutational differences between MC4100(MuLac) and other K-12 sequences were mostly allocated to specific lineages, indicating the considerable mutational divergence between K-12 strains. ...[more]
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