Ontology highlight
ABSTRACT:
SUBMITTER: Mailleux AA
PROVIDER: S-EPMC2698712 | biostudies-literature | 2007 Feb
REPOSITORIES: biostudies-literature
Mailleux Arnaud A AA Overholtzer Michael M Schmelzle Tobias T Bouillet Philippe P Strasser Andreas A Brugge Joan S JS
Developmental cell 20070201 2
The adult, virgin mammary gland is a highly organized tree-like structure formed by ducts with hollowed lumen. Although lumen formation during pubertal development appears to involve apoptosis, the molecular mechanisms that regulate this process are not known. Here, we demonstrate that disruption of the BH3-only proapoptotic factor Bim in mice prevents induction of apoptosis in and clearing of the lumen in terminal end buds during puberty. However, cells that fill the presumptive luminal space a ...[more]