Ontology highlight
ABSTRACT:
SUBMITTER: Frum RA
PROVIDER: S-EPMC2698818 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Frum Rebecca A RA Chastain Paul D PD Qu Pingping P Cohen Stephanie M SM Kaufman David G DG
Cell cycle (Georgetown, Tex.) 20080229 10
During the S phase of the cell cycle, the entire genome is replicated. There is a high level of orderliness to this process through the temporally and topologically coordinated activation of many replication origins situated along chromosomes. We investigated the program of replication from origins initiating in early S phase by labeling synchronized normal human fibroblasts (NHF1) with nucleotide analogs for various pulse times and measuring labeled tracks in combed DNA fibers. Our analysis sho ...[more]