Modulation of hepatocyte phenotype in vitro via chemomechanical tuning of polyelectrolyte multilayers.
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ABSTRACT:
SUBMITTER: Chen AA
PROVIDER: S-EPMC2699113 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Publications
Modulation of hepatocyte phenotype in vitro via chemomechanical tuning of polyelectrolyte multilayers.
Chen Alice A AA Khetani Salman R SR Lee Sunyoung S Bhatia Sangeeta N SN Van Vliet Krystyn J KJ
Biomaterials 20081128 6
It is increasingly appreciated that since cell and tissue functions are regulated by chemomechanical stimuli, precise control over such stimuli will improve the functionality of tissue models. However, due to the inherent difficulty in decoupling these cues as presented by extracellular materials, few studies have explored the independent modulation of biochemical and mechanical stimuli towards the manipulation of sustained cellular processes. Here, we demonstrate that both mechanical compliance ...[more]
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