Ontology highlight
ABSTRACT:
SUBMITTER: Schmiegelow K
PROVIDER: S-EPMC2699230 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Schmiegelow Kjeld K Al-Modhwahi Ibrahim I Andersen Mette Klarskov MK Behrendtz Mikael M Forestier Erik E Hasle Henrik H Heyman Mats M Kristinsson Jon J Nersting Jacob J Nygaard Randi R Svendsen Anne Louise AL Vettenranta Kim K Weinshilboum Richard R
Blood 20090217 24
Among 1614 children with acute lymphoblastic leukemia (ALL) treated with the Nordic Society for Paediatric Haematology and Oncology (NOPHO) ALL-92 protocol, 20 patients developed a second malignant neoplasm (SMN) with a cumulative risk of 1.6% at 12 years from the diagnosis of ALL. Nine of the 16 acute myeloid leukemias or myelodysplastic syndromes had monosomy 7 (n = 7) or 7q deletions (n = 2). In Cox multivariate analysis, longer duration of oral 6-mercaptopurine (6MP)/methotrexate (MTX) maint ...[more]