Regulation of autoimmune arthritis by self-heat-shock proteins.
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ABSTRACT:
SUBMITTER: Moudgil KD
PROVIDER: S-EPMC2699402 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Publications
Regulation of autoimmune arthritis by self-heat-shock proteins.
Moudgil Kamal D KD Durai Malarvizhi M
Trends in immunology 20080901 9
Heat-shock proteins (hsps) are highly conserved and immunogenic, and they are generally perceived to be attractive initiators or targets of a pathogenic immune response, and as such, have been implicated in the pathogenesis of autoimmune arthritis. However, studies in animal models and arthritis patients have unraveled the disease-regulating attributes of self-hsp65. We propose that the self-hsp65 induces a protective and beneficial immune response because of its ubiquitous distribution, stress ...[more]
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