Ontology highlight
ABSTRACT:
SUBMITTER: Basu U
PROVIDER: S-EPMC2699486 | biostudies-literature | 2007 Sep
REPOSITORIES: biostudies-literature
Basu Utpal U Gyrd-Hansen Mads M Baby Santhosh M SM Lozynska Olga O Krag Thomas O B TO Jensen Claus J CJ Frödin Morten M Khurana Tejvir S TS
FEBS letters 20070723 22
Utrophin is the autosomal homolog of dystrophin, the product of the Duchenne's muscular dystrophy (DMD) locus. Utrophin is of therapeutic interest since its over-expression can compensate dystrophin's absence. Utrophin is enriched at neuromuscular junctions due to heregulin-mediated utrophin-A promoter activation. We demonstrate that heregulin activated MSK1/2 and phosphorylated histone H3 at serine 10 in cultured C2C12 muscle cells, in an ERK-dependent manner. MSK1/2 inhibition suppressed hereg ...[more]