Ontology highlight
ABSTRACT:
SUBMITTER: Antoniades C
PROVIDER: S-EPMC2699614 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Antoniades Charalambos C Shirodaria Cheerag C Van Assche Tim T Cunnington Colin C Tegeder Irmgard I Lötsch Jörn J Guzik Tomasz J TJ Leeson Paul P Diesch Jonathan J Tousoulis Dimitris D Stefanadis Christodoulos C Costigan Michael M Woolf Clifford J CJ Alp Nicholas J NJ Channon Keith M KM
Journal of the American College of Cardiology 20080701 2
<h4>Objectives</h4>This study sought to determine the effects of endogenous tetrahydrobiopterin (BH4) bioavailability on endothelial nitric oxide synthase (eNOS) coupling, nitric oxide (NO) bioavailability, and vascular superoxide production in patients with coronary artery disease (CAD).<h4>Background</h4>GTP-cyclohydrolase I, encoded by the GCH1 gene, is the rate-limiting enzyme in the biosynthesis of BH4, an eNOS cofactor important for maintaining enzymatic coupling. We examined the associati ...[more]