Dataset Information

TRIB3 functional Q84R polymorphism is a risk factor for metabolic syndrome and carotid atherosclerosis.

ABSTRACT:

Objective

To determine the association of TRIB3 Q84R polymorphism with metabolic syndrome (MetS) and carotid atherosclerosis.

Research design and methods

A case-control study enrolled 513 Chinese subjects in three groups: control, MetS, and obese. The functional TRIB3 Q84R polymorphism was genotyped among subjects undergoing carotid ultrasonography. The clinical and biochemical characteristics were determined.

Results

For individuals with the TRIB3 R84 allele, the odds ratio for developing MetS was 2.349 (P = 0.018), abdominal obesity 2.351 (P = 0.012), hypertriglyceridemia 2.314 (P = 0.00003), and insulin resistance 1.697 (P = 0.023). Likewise, the odds ratio for individuals with the TRIB3 R84 allele to develop thickened intima-media thickness was 2.208 (P = 0.040).

Conclusions

Individuals with the functional TRIB3 Q84R polymorphism are at risk for MetS. The TRIB3 R84 allele especially predisposes to carotid atherosclerosis in part through the effects of abdominal obesity, hypertriglyceridemia, and insulin resistance.

SUBMITTER: Gong HP

PROVIDER: S-EPMC2699701 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature

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Publications

TRIB3 functional Q84R polymorphism is a risk factor for metabolic syndrome and carotid atherosclerosis.

Gong Hui-ping HP Wang Zhi-hao ZH Jiang Hao H Fang Ning-ning NN Li Ji-sheng JS Shang Yuan-yuan YY Zhang Yun Y Zhong Ming M Zhang Wei W

Diabetes care 20090423 7

<h4>Objective</h4>To determine the association of TRIB3 Q84R polymorphism with metabolic syndrome (MetS) and carotid atherosclerosis.<h4>Research design and methods</h4>A case-control study enrolled 513 Chinese subjects in three groups: control, MetS, and obese. The functional TRIB3 Q84R polymorphism was genotyped among subjects undergoing carotid ultrasonography. The clinical and biochemical characteristics were determined.<h4>Results</h4>For individuals with the TRIB3 R84 allele, the odds rati ...[more]

PMID: 19389818

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Dataset Information

TRIB3 functional Q84R polymorphism is a risk factor for metabolic syndrome and carotid atherosclerosis.

Objective

Research design and methods

Results

Conclusions

Publications

TRIB3 functional Q84R polymorphism is a risk factor for metabolic syndrome and carotid atherosclerosis.

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