Ontology highlight
ABSTRACT:
SUBMITTER: Zhou J
PROVIDER: S-EPMC2700307 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Zhou Jie J Cheng Pingyan P Youn Je-In JI Cotter Matthew J MJ Gabrilovich Dmitry I DI
Immunity 20090611 6
Dendritic cell (DC) differentiation is regulated by stroma via a network of soluble and cell-bound factors. Notch is one of the major elements of this network. Its role in DC differentiation, however, is controversial. Here, we demonstrate that activation of Notch signaling in hematopoietic progenitor cells (HPCs) promoted differentiation of conventional DCs via activation of the canonical Wingless (Wnt) pathway. Inhibition of the Wnt pathway abrogated the effect of Notch on DC differentiation. ...[more]