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Tumor suppressor microRNAs are underrepresented in primary effusion lymphoma and Kaposi sarcoma.


ABSTRACT: The presence of tumor-specific microRNAs reflects tissue of origin and tumor stage. We show that the absence of miRNAs likewise can be used to determine tumor origin (miR-155) and proliferation state because tumor suppressor miRNAs (miR-222/221, let-7 family) were significantly down-regulated in primary effusion lymphoma (PEL) and in Kaposi sarcoma (KS), an endothelial cell tumor. PEL and KS are associated with KS-associated herpesvirus infection. We identified 15 virally regulated miRNAs in latently infected, nontumorigenic endothelial cells. MiR-143/145 were elevated only in KS tumors, not virally infected endothelial cells. Thus, they represent tumor-specific, rather than virus-specific, miRNAs. Because many tumor suppressor proteins are wild-type in KS and PEL, down-regulation of multiple tumor suppressor miRNAs provides a novel, alternative mechanism of transformation.

SUBMITTER: O'Hara AJ 

PROVIDER: S-EPMC2700328 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature

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Tumor suppressor microRNAs are underrepresented in primary effusion lymphoma and Kaposi sarcoma.

O'Hara Andrea J AJ   Wang Ling L   Dezube Bruce J BJ   Harrington William J WJ   Damania Blossom B   Dittmer Dirk P DP  

Blood 20090227 23


The presence of tumor-specific microRNAs reflects tissue of origin and tumor stage. We show that the absence of miRNAs likewise can be used to determine tumor origin (miR-155) and proliferation state because tumor suppressor miRNAs (miR-222/221, let-7 family) were significantly down-regulated in primary effusion lymphoma (PEL) and in Kaposi sarcoma (KS), an endothelial cell tumor. PEL and KS are associated with KS-associated herpesvirus infection. We identified 15 virally regulated miRNAs in lat  ...[more]

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