Ontology highlight
ABSTRACT:
SUBMITTER: O'Hara AJ
PROVIDER: S-EPMC2700328 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
O'Hara Andrea J AJ Wang Ling L Dezube Bruce J BJ Harrington William J WJ Damania Blossom B Dittmer Dirk P DP
Blood 20090227 23
The presence of tumor-specific microRNAs reflects tissue of origin and tumor stage. We show that the absence of miRNAs likewise can be used to determine tumor origin (miR-155) and proliferation state because tumor suppressor miRNAs (miR-222/221, let-7 family) were significantly down-regulated in primary effusion lymphoma (PEL) and in Kaposi sarcoma (KS), an endothelial cell tumor. PEL and KS are associated with KS-associated herpesvirus infection. We identified 15 virally regulated miRNAs in lat ...[more]