Browse
Submit Data
Databases
API
Help

Dataset Information

10 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Temporal frequency channels are linked across audition and touch.

ABSTRACT: Temporal frequency is a fundamental sensory dimension in audition and touch. In audition, analysis of temporal frequency is necessary for speech and music perception; in touch, the spectral analysis of vibratory signals has been implicated in texture perception and in sensing the environment through tools. Environmental oscillations impinging upon the ear are generally thought to be processed independently of oscillations impinging upon the skin. Here, we show that frequency channels are perceptually linked across audition and touch. In a series of psychophysical experiments, we demonstrate that auditory stimuli interfere with tactile frequency perception in a systematic manner. Specifically, performance on a tactile-frequency-discrimination task is impaired when an auditory distractor is presented with the tactile stimuli, but only if the frequencies of the auditory and tactile stimuli are similar. The frequency-dependent interference effect is observed whether the distractors are pure tones or band-pass noise, so an auditory percept of pitch is not required for the effect to be produced. Importantly, distractors that strongly impair frequency discrimination do not interfere with judgments of tactile intensity. This surprisingly specific crosstalk between different modalities reflects the importance of supramodal representations of fundamental sensory dimensions.

SUBMITTER: Yau JM

PROVIDER: S-EPMC2700739 | biostudies-literature |

REPOSITORIES: biostudies-literature

ACCESS DATA

Json Xml

Similar Datasets

Reciprocal Interactions Between Audition and Touch in Flutter Frequency Perception.

Project description:In both audition and touch, sensory cues comprising repeating events are perceived either as a continuous signal or as a stream of temporally discrete events (flutter), depending on the events' repetition rate. At high repetition rates (>100 Hz), auditory and tactile cues interact reciprocally in pitch processing. The frequency of a cue experienced in one modality systematically biases the perceived frequency of a cue experienced in the other modality. Here, we tested whether audition and touch also interact in the processing of low-frequency stimulation. We also tested whether multisensory interactions occurred if the stimulation in one modality comprised click trains and the stimulation in the other modality comprised amplitude-modulated signals. We found that auditory cues bias touch and tactile cues bias audition on a flutter discrimination task. Even though participants were instructed to attend to a single sensory modality and ignore the other cue, the flutter rate in the attended modality is perceived to be similar to that of the distractor modality. Moreover, we observed similar interaction patterns regardless of stimulus type and whether the same stimulus types were experienced by both senses. Combined with earlier studies, our results suggest that the nervous system extracts and combines temporal rate information from multisensory environmental signals, regardless of stimulus type, in both the low- and high temporal frequency domains. This function likely reflects the importance of temporal frequency as a fundamental feature of our multisensory experience.

| S-EPMC7294791 | biostudies-literature

Common or redundant neural circuits for duration processing across audition and touch.

Project description:Certain features of objects or events can be represented by more than a single sensory system, such as roughness of a surface (sight, sound, and touch), the location of a speaker (audition and sight), and the rhythm or duration of an event (by all three major sensory systems). Thus, these properties can be said to be sensory-independent or amodal. A key question is whether common multisensory cortical regions process these amodal features, or does each sensory system contain its own specialized region(s) for processing common features? We tackled this issue by investigating simple duration-detection mechanisms across audition and touch; these systems were chosen because fine duration discriminations are possible in both. The mismatch negativity (MMN) component of the human event-related potential provides a sensitive metric of duration processing and has been elicited independently during both auditory and somatosensory investigations. Employing high-density electroencephalographic recordings in conjunction with intracranial subdural recordings, we asked whether fine duration discriminations, represented by the MMN, were generated in the same cortical regions regardless of the sensory modality being probed. Scalp recordings pointed to statistically distinct MMN topographies across senses, implying differential underlying cortical generator configurations. Intracranial recordings confirmed these noninvasive findings, showing generators of the auditory MMN along the superior temporal gyrus with no evidence of a somatosensory MMN in this region, whereas a robust somatosensory MMN was recorded from postcentral gyrus in the absence of an auditory MMN. The current data clearly argue against a common circuitry account for amodal duration processing.

| S-EPMC3204366 | biostudies-literature

The frequency of cortical microstimulation shapes artificial touch.

Project description:Intracortical microstimulation (ICMS) of the somatosensory cortex evokes vivid tactile sensations and can be used to convey sensory feedback from brain-controlled bionic hands. Changes in ICMS frequency lead to changes in the resulting sensation, but the discriminability of frequency has only been investigated over a narrow range of low frequencies. Furthermore, the sensory correlates of changes in ICMS frequency remain poorly understood. Specifically, it remains to be elucidated whether changes in frequency only modulate sensation magnitude-as do changes in amplitude-or whether they also modulate the quality of the sensation. To fill these gaps, we trained monkeys to discriminate the frequency of ICMS pulse trains over a wide range of frequencies (from 10 to 400 Hz). ICMS amplitude also varied across stimuli to dissociate sensation magnitude from ICMS frequency and ensure that animals could not make frequency judgments based on magnitude. We found that animals could consistently discriminate ICMS frequency up to ∼200 Hz but that the sensory correlates of frequency were highly electrode dependent: On some electrodes, changes in frequency were perceptually distinguishable from changes in amplitude-seemingly giving rise to a change in sensory quality; on others, they were not. We discuss the implications of our findings for neural coding and for brain-controlled bionic hands.

| S-EPMC6969512 | biostudies-literature

Stretch-activated ion channels identified in the touch-sensitive structures of carnivorous Droseraceae plants.

Project description:We compare isolated trigger hairs from Venus flytrap leaves to whole trap tissue (with trigger hairs removed) to find differentially-expressed transcripts.

2021-01-07 | GSE131340 | GEO

Neuronal Oscillations in Various Frequency Bands Differ between Pain and Touch.

Project description:Although humans are generally capable of distinguishing single events of pain or touch, recent research suggested that both modalities activate a network of similar brain regions. By contrast, less attention has been paid to which processes uniquely contribute to each modality. The present study investigated the neuronal oscillations that enable a subject to process pain and touch as well as to evaluate the intensity of both modalities by means of Electroencephalography. Nineteen healthy subjects were asked to rate the intensity of each stimulus at single trial level. By computing Linear mixed effects models (LME) encoding of both modalities was explored by relating stimulus intensities to brain responses. While the intensity of single touch trials is encoded only by theta activity, pain perception is encoded by theta, alpha and gamma activity. Beta activity in the tactile domain shows an on/off like characteristic in response to touch which was not observed in the pain domain. Our results enhance recent findings pointing to the contribution of different neuronal oscillations to the processing of nociceptive and tactile stimuli.

| S-EPMC4850848 | biostudies-literature

Touch, Tension, and Transduction - The Function and Regulation of Piezo Ion Channels.

Project description:In 2010, two proteins, Piezo1 and Piezo2, were identified as the long-sought molecular carriers of an excitatory mechanically activated current found in many cells. This discovery has opened the floodgates for studying a vast number of mechanotransduction processes. Over the past 6 years, groundbreaking research has identified Piezos as ion channels that sense light touch, proprioception, and vascular blood flow, ruled out roles for Piezos in several other mechanotransduction processes, and revealed the basic structural and functional properties of the channel. Here, we review these findings and discuss the many aspects of Piezo function that remain mysterious, including how Piezos convert a variety of mechanical stimuli into channel activation and subsequent inactivation, and what molecules and mechanisms modulate Piezo function.

| S-EPMC5407468 | biostudies-literature

Caldendrin Is a Repressor of PIEZO2 Channels and Touch Sensation in Mice.

Project description:The sense of touch is crucial for cognitive, emotional, and social development and relies on mechanically activated (MA) ion channels that transduce force into an electrical signal. Despite advances in the molecular characterization of these channels, the physiological factors that control their activity are poorly understood. Here, we used behavioral assays, electrophysiological recordings, and various mouse strains (males and females analyzed separately) to investigate the role of the calmodulin-like Ca2+ sensor, caldendrin, as a key regulator of MA channels and their roles in touch sensation. In mice lacking caldendrin (Cabp1 KO), heightened responses to tactile stimuli correlate with enlarged MA currents with lower mechanical thresholds in dorsal root ganglion neurons (DRGNs). The expression pattern of caldendrin in the DRG parallels that of the major MA channel required for touch sensation, PIEZO2. In transfected cells, caldendrin interacts with and inhibits the activity of PIEZO2 in a manner that requires an alternatively spliced sequence in the N-terminal domain of caldendrin. Moreover, targeted genetic deletion of caldendrin in Piezo2-expressing DRGNs phenocopies the tactile hypersensitivity of complete Cabp1 KO mice. We conclude that caldendrin is an endogenous repressor of PIEZO2 channels and their contributions to touch sensation in DRGNs.

| S-EPMC10919251 | biostudies-literature

The neural circuits and sensory channels mediating harsh touch sensation in Caenorhabditis elegans.

Project description:Most animals can distinguish two distinct types of touch stimuli: gentle (innocuous) and harsh (noxious/painful) touch, however, the underlying mechanisms are not well understood. Caenorhabditis elegans is a useful model for the study of gentle touch sensation. However, little is known about harsh touch sensation in this organism. Here we characterize harsh touch sensation in C. elegans. We show that C. elegans exhibits differential behavioural responses to harsh touch and gentle touch. Laser ablations identify distinct sets of sensory neurons and interneurons required for harsh touch sensation at different body segments. Optogenetic stimulation of the circuitry can drive behaviour. Patch-clamp recordings reveal that TRP family and amiloride-sensitive Na(+) channels mediate touch-evoked currents in different sensory neurons. Our work identifies the neural circuits and characterizes the sensory channels mediating harsh touch sensation in C. elegans, establishing it as a genetic model for studying this sensory modality.

| S-EPMC3098610 | biostudies-literature

Tuning Piezo ion channels to detect molecular-scale movements relevant for fine touch.

Project description:In sensory neurons, mechanotransduction is sensitive, fast and requires mechanosensitive ion channels. Here we develop a new method to directly monitor mechanotransduction at defined regions of the cell-substrate interface. We show that molecular-scale (~13 nm) displacements are sufficient to gate mechanosensitive currents in mouse touch receptors. Using neurons from knockout mice, we show that displacement thresholds increase by one order of magnitude in the absence of stomatin-like protein 3 (STOML3). Piezo1 is the founding member of a class of mammalian stretch-activated ion channels, and we show that STOML3, but not other stomatin-domain proteins, brings the activation threshold for Piezo1 and Piezo2 currents down to ~10 nm. Structure-function experiments localize the Piezo modulatory activity of STOML3 to the stomatin domain, and higher-order scaffolds are a prerequisite for function. STOML3 is the first potent modulator of Piezo channels that tunes the sensitivity of mechanically gated channels to detect molecular-scale stimuli relevant for fine touch.

| S-EPMC3973071 | biostudies-literature

Tribotronic bipolar junction transistor for mechanical frequency monitoring and use as touch switch.

Project description:Tribotronics, a new field that involves the coupling of triboelectricity and semiconductors, has attracted great interest in the nanoenergy and nanoelectronics domains. This paper proposes a tribotronic bipolar junction transistor (TBJT) that incorporates a bipolar junction transistor and a triboelectric nanogenerator (TENG) in the single-electrode mode. When the mobile triboelectric layer slides on the device surface for electrification, a bias voltage is created and applied to the emitter junction, and then the base current from the TENG is amplified. Based on the fabricated TBJT, a mechanical frequency monitoring sensor with high sensitivity and excellent stability and a finger-triggered touch switch were developed. This work demonstrated for the first time a tribotronic device with simultaneously controlled voltage and current voltage/current simultaneously controlled tribotronic device, which has promising potential applications in micro/nano-sensors, human-machine interactions, intelligent instrumentation, wearable electronics, and other applications.

| S-EPMC6220156 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data