Ontology highlight
ABSTRACT:
SUBMITTER: Ricklin D
PROVIDER: S-EPMC2700864 | biostudies-literature | 2008
REPOSITORIES: biostudies-literature
Ricklin Daniel D Lambris John D JD
Advances in experimental medicine and biology 20080101
Therapeutic modulation of the human complement system is considered a promising approach for treating a number of pathological conditions. Owing to its central position in the cascade, component C3 is a particularly attractive target for complement-specific drugs. Compstatin, a cyclic tridecapeptide, which was originally discovered from phage-display libraries, is a highly potent and selective C3 inhibitor that demonstrated clinical potential in a series of experimental models. A combination of ...[more]