Ontology highlight
ABSTRACT:
SUBMITTER: Venkiteswaran G
PROVIDER: S-EPMC2700899 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Venkiteswaran Gayatri G Hasan Gaiti G
Proceedings of the National Academy of Sciences of the United States of America 20090610 25
Neuronal Ca(2+) signals can affect excitability and neural circuit formation. Ca(2+) signals are modified by Ca(2+) flux from intracellular stores as well as the extracellular milieu. However, the contribution of intracellular Ca(2+) stores and their release to neuronal processes is poorly understood. Here, we show by neuron-specific siRNA depletion that activity of the recently identified store-operated channel encoded by dOrai and the endoplasmic reticulum Ca(2+) store sensor encoded by dSTIM ...[more]