Ontology highlight
ABSTRACT:
SUBMITTER: Wang S
PROVIDER: S-EPMC2701002 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Wang Sui S Jensen Jan N JN Seymour Philip A PA Hsu Wei W Dor Yuval Y Sander Maike M Magnuson Mark A MA Serup Palle P Gu Guoqiang G
Proceedings of the National Academy of Sciences of the United States of America 20090601 24
Neurog3 (Neurogenin 3 or Ngn3) is both necessary and sufficient to induce endocrine islet cell differentiation from embryonic pancreatic progenitors. Since robust Neurog3 expression has not been detected in hormone-expressing cells, Neurog3 is used as an endocrine progenitor marker and regarded as dispensable for the function of differentiated islet cells. Here we used 3 independent lines of Neurog3 knock-in reporter mice and mRNA/protein-based assays to examine Neurog3 expression in hormone-exp ...[more]