Ontology highlight
ABSTRACT:
SUBMITTER: Huang K
PROVIDER: S-EPMC2701197 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
The Journal of organic chemistry 20080501 11
An asymmetric synthesis for the preparation of nonracemic amines bearing heterocyclic and heteroaromatic rings is described. A variety of important enantiopure thionyl and arylalkyl primary amines were afforded by the borane-mediated enantioselective reduction of O-benzyl ketoximes using 10% of catalyst 10 derived from ( S)-diphenylvalinol and ethylene glycol with excellent enantioselectivity, in up to 99% ee. The optimal condition for the first asymmetric reduction of 3- and 4-pyridyl-derived O ...[more]