Ontology highlight
ABSTRACT:
SUBMITTER: Takakura A
PROVIDER: S-EPMC2701325 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Takakura Ayumi A Contrino Leah L Zhou Xiangzhi X Bonventre Joseph V JV Sun Yanping Y Humphreys Benjamin D BD Zhou Jing J
Human molecular genetics 20090402 14
The 'two-hit' model is a widely accepted genetic mechanism for progressive cyst formation in autosomal dominant polycystic kidney disease. We have previously shown that adult inactivation of Pkd1 using the Mx1Cre(+) allele causes a late onset of focal cystic disease. An explanation for the delayed appearance of cysts is the requirement for an additional independent factor, or 'third hit'. Here we show that renal injury leads to massive cystic disease in the same mouse line. Cysts are labeled wit ...[more]