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Role of ABCC2 common variants in intrahepatic cholestasis of pregnancy.

ABSTRACT: The pathogenesis of intrahepatic cholestasis of pregnancy (ICP), a disorder that adversely affects maternal wellbeing and fetal outcome, is unclear. However, multiple factors probably interact along with a genetic predisposition. We would like to add some comments on a paper recently published concerning the role of ABCB11 and ABCC2 polymorphisms in both ICP and contraceptive-induced cholestasis, especially in the light of our recently published findings about a positive association between ICP and ABCC2 common variants.

SUBMITTER: Sookoian S

PROVIDER: S-EPMC2701541 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature

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Role of ABCC2 common variants in intrahepatic cholestasis of pregnancy.

Sookoian Silvia S Castano Gustavo G Pirola Carlos-J CJ

World journal of gastroenterology 20080401 13

The pathogenesis of intrahepatic cholestasis of pregnancy (ICP), a disorder that adversely affects maternal wellbeing and fetal outcome, is unclear. However, multiple factors probably interact along with a genetic predisposition. We would like to add some comments on a paper recently published concerning the role of ABCB11 and ABCC2 polymorphisms in both ICP and contraceptive-induced cholestasis, especially in the light of our recently published findings about a positive association between ICP ...[more]

PMID: 18395921

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