Structural analogs of tylophora alkaloids may not be functional analogs.
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ABSTRACT:
SUBMITTER: Gao W
PROVIDER: S-EPMC2701548 | biostudies-literature | 2008 Jan
REPOSITORIES: biostudies-literature
Publications
Structural analogs of tylophora alkaloids may not be functional analogs.
Gao Wenli W Chen Annie Pei-Chun AP Leung Chung-Hang CH Gullen Elizabeth A EA Fürstner Alois A Shi Qian Q Wei Linyi L Lee Kuo-Hsiung KH Cheng Yung-Chi YC
Bioorganic & medicinal chemistry letters 20071121 2
Phenanthroindolizidine-based tylophora alkaloids have been reported to have potential antitumor, anti-immuno and, anti-inflammatory activity. The structure-activity relationships of a series of tylophora alkaloids were studied to guide future drug design. Our results indicate that although these compounds are structural analogs, their potency of cytotoxicity, selectivity against NF-kappaB signaling pathway, and their inhibitory effects against protein and nucleic acid synthesis are different. Be ...[more]
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