Functions of the intermediate filament cytoskeleton in the eye lens.
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ABSTRACT:
SUBMITTER: Song S
PROVIDER: S-EPMC2701874 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Publications
Functions of the intermediate filament cytoskeleton in the eye lens.
Song Shuhua S Landsbury Andrew A Dahm Ralf R Liu Yizhi Y Zhang Qingjiong Q Quinlan Roy A RA
The Journal of clinical investigation 20090701 7
Intermediate filaments (IFs) are a key component of the cytoskeleton in virtually all vertebrate cells, including those of the lens of the eye. IFs help integrate individual cells into their respective tissues. This Review focuses on the lens-specific IF proteins beaded filament structural proteins 1 and 2 (BFSP1 and BFSP2) and their role in lens physiology and disease. Evidence generated in studies in both mice and humans suggests a critical role for these proteins and their filamentous polymer ...[more]
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