Molecular evolution and population genetics of two Drosophila mettleri cytochrome P450 genes involved in host plant utilization.

ABSTRACT: Understanding the genetic basis of adaptation is one of the primary goals of evolutionary biology. The evolution of xenobiotic resistance in insects has proven to be an especially suitable arena for studying the genetics of adaptation, and resistant phenotypes are known to result from both coding and regulatory changes. In this study, we examine the evolutionary history and population genetics of two Drosophila mettleri cytochrome P450 genes that are putatively involved in the detoxification of alkaloids present in two of its cactus hosts: saguaro (Carnegiea gigantea) and senita (Lophocereus schottii). Previous studies demonstrated that Cyp28A1 was highly up-regulated following exposure to rotting senita tissue while Cyp4D10 was highly up-regulated following exposure to rotting saguaro tis

SUBMITTER: Bono JM 

PROVIDER: S-EPMC2702709 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature