Structural domains in RNAi.
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ABSTRACT:
SUBMITTER: Collins RE
PROVIDER: S-EPMC2702771 | biostudies-literature | 2005 Oct
REPOSITORIES: biostudies-literature
Publications
Structural and biochemical studies have begun to elucidate the pathway of RNA silencing that leads to the formation of the RISC complex. The outstanding feature of this pathway is the precise recognition and processing of double-stranded RNA. We present a review of recent structures that illustrate the molecular mechanisms contributing to these two related functions, highlighting models of Drosha, Dicer, and RISC function. ...[more]
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