Activation of PKR: an open and shut case?
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ABSTRACT:
SUBMITTER: Cole JL
PROVIDER: S-EPMC2703476 | biostudies-literature | 2007 Feb
REPOSITORIES: biostudies-literature
Publications
The double-stranded (ds) RNA-activated protein kinase, PKR, has a key role in the innate immunity response to viral infection in higher eukaryotes. PKR contains an N-terminal dsRNA-binding domain and a C-terminal kinase domain. In the prevalent autoinhibition model for PKR activation, dsRNA binding induces a conformational change that leads to the release of the dsRNA-binding domain from the kinase, thus relieving the inhibition of the latent enzyme. Structural and biophysical data now favor a m ...[more]
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