Ontology highlight
ABSTRACT:
SUBMITTER: Elinav E
PROVIDER: S-EPMC2703547 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Elinav Eran E Niv-Spector Leonora L Katz Meirav M Price Tulin O TO Ali Mohammed M Yacobovitz Michal M Solomon Gili G Reicher Shay S Lynch Jessica L JL Halpern Zamir Z Banks William A WA Gertler Arieh A
Endocrinology 20090402 7
Leptin, a pleiotropic adipokine, is a central regulator of appetite and weight and a key immunomodulatory protein. Although inborn leptin deficiency causes weight gain, it is unclear whether induced leptin deficiency in adult wild-type animals would be orexigenic. Previous work with a potent competitive leptin antagonist did not induce a true metabolic state of leptin deficiency in mice because of a short circulating half-life. In this study, we increased the half-life of the leptin antagonist b ...[more]