Ontology highlight
ABSTRACT:
SUBMITTER: Xiong W
PROVIDER: S-EPMC2703652 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
Xiong Weidong W Candolfi Marianela M Kroeger Kurt M KM Puntel Mariana M Mondkar Sonali S Larocque Daniel D Liu Chunyan C Curtin James F JF Palmer Donna D Ng Philip P Lowenstein Pedro R PR Castro Maria G MG
Molecular therapy : the journal of the American Society of Gene Therapy 20080108 2
Immune responses against vectors or encoded transgenes can impose limitations on gene therapy. We demonstrated that tetracycline-regulated high-capacity adenoviral vectors (HC-Ads) sustain regulated transgene expression in the brain even in the presence of systemic pre-existing immune responses against adenoviruses. In this study we assessed whether systemic pre-existing immune responses against the transgene products, i.e., beta-Gal or the tetracycline-dependent (TetON) regulatory transcription ...[more]