PathExpress update: the enzyme neighbourhood method of associating gene-expression data with metabolic pathways.
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ABSTRACT:
SUBMITTER: Goffard N
PROVIDER: S-EPMC2703986 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Publications
PathExpress update: the enzyme neighbourhood method of associating gene-expression data with metabolic pathways.
Goffard Nicolas N Frickey Tancred T Weiller Georg G
Nucleic acids research 20090527 Web Server issue
The post-genomic era presents us with the challenge of linking the vast amount of raw data obtained with transcriptomic and proteomic techniques to relevant biological pathways. We present an update of PathExpress, a web-based tool to interpret gene-expression data and explore the metabolic network without being restricted to predefined pathways. We define the Enzyme Neighbourhood (EN) as a sub-network of linked enzymes with a limited path length to identify the most relevant sub-networks affect ...[more]
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